MOXIFLOXACIN+LOTEPREDNOL ETABONATE
About
LOTEPREDNOL ETABONATE+MOXIFLOXACIN belongs to a group of medications called ‘Antibiotics and Corticosteroids’ used to treat bacterial eye infections or eye discomfort. It is also used in patients who have undergone eye surgeries. It is used to treat eye inflammation caused by allergies, shingles, iritis (inflammation of the coloured part of the eye (iris)), uveitis (inflammation of the middle layer of the eye (uvea)), eye injury, radiation, and chemical burns. A bacterial eye infection occurs when bacteria invade any part of the eyeball or its surrounding tissues, including the cornea (clear front surface of the eye) and the conjunctiva (thin membrane lining the outer eye and inner eyelids). LOTEPREDNOL ETABONATE+MOXIFLOXACIN is used to prevent or treat only bacterial eye infections. It does not work against infections caused by viruses and fungus.
LOTEPREDNOL ETABONATE+MOXIFLOXACIN contains two medicines, namely: Moxifloxacin (antibiotic) and Loteprednol etabonate (corticosteroid). Moxifloxacin belongs to a class of drugs called fluoroquinolone antibiotics that helps in treating and preventing a wide range of bacterial infections. It kills bacteria (bactericidal action) by preventing the synthesis of enzymes, namely DNA gyrase and Topoisomerase II and IV, which is essential for the growth and survival of the bacterial cell. Loteprednol etabonate belongs to the class of corticosteroids. It blocks prostaglandins' production (chemical messengers) that make the eye red, swollen, and itchy. Together, LOTEPREDNOL ETABONATE+MOXIFLOXACIN prevents the spread of eye infections caused by bacteria, and also reduces inflammation and pain.
LOTEPREDNOL ETABONATE+MOXIFLOXACIN is for ophthalmic use only. Your doctor will advise on how often you need to use LOTEPREDNOL ETABONATE+MOXIFLOXACIN based on your medical condition. Some common side effects of LOTEPREDNOL ETABONATE+MOXIFLOXACIN include redness in the eyes, blurred vision, burning or stinging sensation in the eye, and eye discomfort. These side effects do not require medical attention and gradually resolve over time. However, you are advised to consult your doctor if you experience any of the side effects persistently.
Please do not use LOTEPREDNOL ETABONATE+MOXIFLOXACIN without consulting your doctor if you have damaged cornea, ulcers in the eye, eye infection, pus, open lesions in the eye, and glaucoma (a condition where the pressure inside the eye is increased). Inform your doctor if you are pregnant or breastfeeding before using LOTEPREDNOL ETABONATE+MOXIFLOXACIN. Avoid touching the eyedropper with bare hands or to the eyelids while administering drops, since it contaminates the dropper tip and solution. If you wear contact lenses, please inform your doctor since LOTEPREDNOL ETABONATE+MOXIFLOXACIN may contain additives like Benzalkonium chloride that change the colour. LOTEPREDNOL ETABONATE+MOXIFLOXACIN sometimes may make your eye red after administration; in such cases, please avoid wearing a lens until the eye becomes better. LOTEPREDNOL ETABONATE+MOXIFLOXACIN might temporarily blur your vision, so avoid driving, or operating machines until your vision is clear.
Uses of MOXIFLOXACIN+LOTEPREDNOL ETABONATE
Medicinal Benefits
LOTEPREDNOL ETABONATE+MOXIFLOXACIN contains Moxifloxacin and Loteprednol etabonate. Moxifloxacin is a broad-spectrum antibiotic that acts against both gram-positive and gram-negative bacteria. It kills bacteria (bactericidal action) by preventing the synthesis of enzymes, namely DNA gyrase and Topoisomerase II and IV, which is essential for the growth and survival of the bacterial cell. Loteprednol etabonate is a corticosteroid with anti-inflammatory properties and acts by inhibiting the chemicals such as prostaglandins production (chemical messengers) that make the eye red, swollen, and itchy. It reduces symptoms associated with infection such as redness and irritation of the eye and decreases the risk of infections. Collectively, LOTEPREDNOL ETABONATE+MOXIFLOXACIN treats and prevents bacterial eye infections and eye inflammation caused by allergies, shingles, iritis (inflammation of the coloured part of the eye (iris), uveitis (inflammation of the middle layer of the eye (uvea), eye injury, radiation, and chemical burns.
Directions for Use
Storage
Side Effects of MOXIFLOXACIN+LOTEPREDNOL ETABONATE
- Blurred vision
- Burning/stinging sensation in the eyes
- Redness in the eyes
- Watery eyes
- Inflammation of cornea
In-Depth Precautions and Warning
Drug Warnings
If you are allergic to LOTEPREDNOL ETABONATE+MOXIFLOXACIN or any other medicines, please tell your doctor. Before taking LOTEPREDNOL ETABONATE+MOXIFLOXACIN, inform your doctor if you have vision problems, severe pain in the eye, ulcers in the eye, glaucoma (raised pressure in the eye), eye injury or have undergone eye surgery or using any other eye drops or eye ointment. If you wear contact lenses, please inform your doctor since LOTEPREDNOL ETABONATE+MOXIFLOXACIN may contain additives like Benzalkonium chloride that change the lens's colour. LOTEPREDNOL ETABONATE+MOXIFLOXACIN sometimes may make your eye red after administration; in such cases, please avoid wearing a lens until the eye becomes better. Do not use eye drops for longer than recommended by your doctor as it may increase the risk of cataracts (clouding of the eye) and increase the risk of a second infection. Inform your doctor immediately if you notice any persistent visual disturbances while using this medicine. It is advised to check with your doctor before using LOTEPREDNOL ETABONATE+MOXIFLOXACIN if you are pregnant or breastfeeding. LOTEPREDNOL ETABONATE+MOXIFLOXACIN may cause temporary blurred vision immediately after using. Therefore, wait until your vision is clear before driving or operating machinery.
Drug Interactions
Drug-Drug Interactions: LOTEPREDNOL ETABONATE+MOXIFLOXACIN may interact with anti-HIV drugs (ritonavir, cobicistat). Also, inform your doctor if you are using eye drops for treatment of high pressure in the eyes and anticholinergics.
Drug-Food Interactions: No interaction found.
Drug-Disease Interactions: LOTEPREDNOL ETABONATE+MOXIFLOXACIN should not be used in patients with fungal eye infections, viral infections such as herpes simplex or varicella, parasitic infections, damaged cornea, and glaucoma (increased pressure inside the eye).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionThe interaction of alcohol with LOTEPREDNOL ETABONATE+MOXIFLOXACIN is unknown. Please consult a doctor before consuming alcohol with LOTEPREDNOL ETABONATE+MOXIFLOXACIN.
Pregnancy
cautionPlease consult a doctor if you are pregnant. LOTEPREDNOL ETABONATE+MOXIFLOXACIN is prescribed to pregnant women only if the doctor thinks the benefits outweigh the risks.
Breast Feeding
cautionLOTEPREDNOL ETABONATE+MOXIFLOXACIN is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks. Please consult a doctor if you are breastfeeding.
Driving
cautionLOTEPREDNOL ETABONATE+MOXIFLOXACIN may cause temporary blurred vision immediately after using. Therefore, wait until your vision is clear before driving or operating machinery.
Liver
cautionIf you have any concerns regarding the use of LOTEPREDNOL ETABONATE+MOXIFLOXACIN in patients with liver problems, please consult a doctor.
Kidney
cautionIf you have any concerns regarding the use of LOTEPREDNOL ETABONATE+MOXIFLOXACIN in patients with kidney problems, please consult a doctor.
Children
cautionLOTEPREDNOL ETABONATE+MOXIFLOXACIN should be used with caution in children. It is not recommended for use in newborns.
Habit Forming
Diet & Lifestyle Advise
- Sleep for minimum 6 to 8 hours to rejuvenate your eyes naturally.
- Wash your eyes with clean water at least two to three times a day. Do not wash your eyes if you have undergone any eye surgery for at least 2 weeks.
- Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
- Eat foods rich in Omega-3 fatty acids such as sardines, mackerel, tuna, salmon, trout and include omega-3 fatty acid supplements.
- Cut down your coffee intake as it may increase pressure in the eye. Replace coffee with green tea.
- Maintain a diet rich in antioxidants such as dark-green leafy vegetables, whole grains, citrus fruits, broccoli, Brussels sprouts, etc.
- Avoid consumption of processed foods such as high-fat meats, sugary foods, dairy products, and fast foods as they may increase inflammation.
Special Advise
- Please consult an eye specialist if your eye infection persists or worsens after using LOTEPREDNOL ETABONATE+MOXIFLOXACIN for a week.
- Have frequent follow-up check-ups with your doctor to check for any problems such as cataracts, an increase in pressure, or infections if prescribed for long-term use.
Patients Concern
Disease/Condition Glossary
Bacterial eye infections: The common bacterial eye infections are conjunctivitis, stye, or keratitis. Conjunctivitis (pink eye) is the infection or inflammation of the conjunctiva (white part of the eye) and the inner eyelid. It is a highly contagious infection that is spread by secretions of the eye. Symptoms include redness, itchy, and discharge or crusting around the eye. A stye is a bump on the eyelid, which is also a common eye condition. Keratitis is the inflammation of the cornea that occurs due to frequent usage of contact lenses, injury, diabetes, or surgery.
FAQs
LOTEPREDNOL ETABONATE+MOXIFLOXACIN contains Moxifloxacin and Loteprednol etabonate. Moxifloxacin is an antibiotic that prevents bacterial cells from dividing and repairing, thereby killing the bacteria. Loteprednol etabonate, a corticosteroid, blocks the production of prostaglandins (chemical messengers) that make the eye red, swollen and itchy. Collectively, LOTEPREDNOL ETABONATE+MOXIFLOXACIN helps in relieving and treating symptoms of bacterial eye infections.
You are not recommended to stop using LOTEPREDNOL ETABONATE+MOXIFLOXACIN without consulting your doctor even if you feel better. Your symptoms may improve before the infection is completely cured. Therefore, use LOTEPREDNOL ETABONATE+MOXIFLOXACIN for as long as your doctor has prescribed it, and if you experience any difficulty while using LOTEPREDNOL ETABONATE+MOXIFLOXACIN, please consult your doctor.
If you are using other eye drops along with LOTEPREDNOL ETABONATE+MOXIFLOXACIN, maintain an interval of at least 10 minutes before administering other medicines in the same eye to avoid dilution.
LOTEPREDNOL ETABONATE+MOXIFLOXACIN is generally prescribed for 7 days. You should use this medicine for a duration prescribed by your doctor. Avoid prolonged use, as it may cause cataracts (clouding of the eye) and increase the second infection risk. If you use LOTEPREDNOL ETABONATE+MOXIFLOXACIN for longer than 10 days, you may need frequent vision tests to check the pressure inside your eyes.
LOTEPREDNOL ETABONATE+MOXIFLOXACIN can cause a blurry vision for some time in the beginning. Avoid driving and operating machinery in such cases until you feel better. If the effect persists longer, seek medical attention.
You are not recommended to wear contact lenses while using LOTEPREDNOL ETABONATE+MOXIFLOXACIN as it contains benzalkonium chloride, a preservative that changes the colour of contact lens as it may be absorbed by soft contact lens. Benzalkonium chloride also causes irritation in the eye especially if you have disorders of cornea (transparent layer at the front of eye) or dry eyes. Therefore, you are advised to remove contact lenses before applying LOTEPREDNOL ETABONATE+MOXIFLOXACIN and reinsert after 15 minutes of using LOTEPREDNOL ETABONATE+MOXIFLOXACIN. Also, inform your doctor if you experience pain, stinging or abnormal sensation in the eye after using LOTEPREDNOL ETABONATE+MOXIFLOXACIN.
